CareLit · DOI-Nachweis · Pneumologie
Intestinal Current Measurements Detect Activation of Mutant CFTR in Cystic Fibrosis Patients with the G551D Mutation Treated with Ivacaftor
DOI 10.1055/s-0035-1556594
Bibliografische Angaben
Nachweis in CareLit
Autor:innenS Gräber, M Hug, O Sommerburg, S Hirtz, J Hentschel, A Heinzmann, C Dopfer, A Schulz, J Mainz, B Tümmler, MA Mall
ZeitschriftPneumologie
Ausgabe07/2015
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
Introduction: Recent studies suggest that sensitive outcome measures of in vivo CFTR activity may be important to accelerate clinical development of emerging CFTR modulator therapies for cystic fibrosis (CF). Intestinal current measurements (ICM) detect pharmacological activation of mutant CFTR ex vivo. However, whether ICM can detect rescue of mutant CFTR function in CF patients remains unknown. Objective: To deter…
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Zitierempfehlung
S Gräber, M Hug, O Sommerburg, S Hirtz, J Hentschel, A Heinzmann, C Dopfer, A Schulz, J Mainz, B Tümmler, MA Mall (2015) Intestinal Current Measurements Detect Activation of Mutant CFTR in Cystic Fibrosis Patients with the G551D Mutation Treated with Ivacaftor. Pneumologie (07). https://doi.org/10.1055/s-0035-1556594
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