CareLit · DOI-Nachweis · Pneumologie
IL-1 receptor anatagonist anakinra reduces neutrophilic airway inflammation in mice with cystic fibrosis-like lung disease
DOI 10.1055/s-0035-1556597
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Nachweis in CareLit
Autor:innenZ Zhou-Suckow, B Fritzsching, J Schatterny, S Hirtz, S Schmidt, E Maier, MA Mall
ZeitschriftPneumologie
Ausgabe07/2015
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
Hypoxic degeneration and necrosis of epithelial cells associated with airway mucus obstruction precedes neutrophilic airway inflammation in βENaC-overexpressing (βENaC-Tg) mice with cystic fibrosis (CF)-like lung disease (Mall MA et al., Am J Respir Crit Care Med., 2008). In many organs sterile neutrophilic inflammation is triggered by necrosis via release of Interleukin-1 alpha (IL-1α) and IL-1 receptor (IL-1R) sig…
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Zitierempfehlung
Z Zhou-Suckow, B Fritzsching, J Schatterny, S Hirtz, S Schmidt, E Maier, MA Mall (2015) IL-1 receptor anatagonist anakinra reduces neutrophilic airway inflammation in mice with cystic fibrosis-like lung disease. Pneumologie (07). https://doi.org/10.1055/s-0035-1556597
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