CareLit · DOI-Nachweis · Pneumologie
Generation of disease-specific iPSCs and development of transgenic reporter cell lines for cystic fibrosis disease modelling and drug screening
DOI 10.1055/s-0035-1556600
Bibliografische Angaben
Nachweis in CareLit
Autor:innenM Schubert, S Merkert, A Haase, L Engels, R Haller, N Lachmann, T Moritz, B Tümmler, L Galietta, U Martin
ZeitschriftPneumologie
Ausgabe07/2015
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
Introduction: Cystic fibrosis (CF) is a genetic disorder caused by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene coding for a cAMP-activated chloride-channel expressed in different epithelia. So far, immortalized cell lines overexpressing mutant CFTR-variants have been used to screen compound libraries. In fact, CFTR-protein-modulators have been identified, but show modest effects…
Zitieren
Zitierempfehlung
M Schubert, S Merkert, A Haase, L Engels, R Haller, N Lachmann, T Moritz, B Tümmler, L Galietta, U Martin (2015) Generation of disease-specific iPSCs and development of transgenic reporter cell lines for cystic fibrosis disease modelling and drug screening. Pneumologie (07). https://doi.org/10.1055/s-0035-1556600
Mit CareLit weiterarbeiten