CareLit · DOI-Nachweis · Pneumologie
Small molecule inhibitor of neutrophil elastase reduces emphysema in mice with cystic fibrosis-like lung disease
DOI 10.1055/s-0035-1556602
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Nachweis in CareLit
Autor:innenC Wagner, J Schatterny, S Gehrig, Z Zhou-Suckow, C Schultz, MA Mall
ZeitschriftPneumologie
Ausgabe07/2015
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
Background: Increased neutrophil elastase (NE) activity in bronchoalveolar lavage (BAL) fluid in newborns with cystic fibrosis (CF) has been shown to correlate with lung damage in juvenile age. Mice with airway- specific overexpression of the epithelial Na+ channel (βENaC-Tg) phenocopy CF lung disease with mucus obstruction, chronic inflammation and emphysema. Genetic deletion of NE in βENaC-Tg mice reduced airway i…
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Zitierempfehlung
C Wagner, J Schatterny, S Gehrig, Z Zhou-Suckow, C Schultz, MA Mall (2015) Small molecule inhibitor of neutrophil elastase reduces emphysema in mice with cystic fibrosis-like lung disease. Pneumologie (07). https://doi.org/10.1055/s-0035-1556602
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