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Development of Confocal Reflection Microscopy for the Study of Airway Surface Liquid Dysregulation in Cystic Fibrosis

A Seyhan Agircan, M Lampe, J Duerr, R Pepperkok, MA Mall · Pneumologie · Ausgabe 07/2015

DOI 10.1055/s-0035-1556607

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Autor:innenA Seyhan Agircan, M Lampe, J Duerr, R Pepperkok, MA Mall
ZeitschriftPneumologie
Ausgabe07/2015
Jahrgang / SeitenNicht angegeben

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Abstract-Vorschau

In cystic fibrosis(CF) patients and βENaC-overexpressing mice, impaired airway epithelial ion transport produces airway surface liquid(ASL) depletion, leading to mucociliary dysfunction, mucus obstruction, chronic airway inflammation and infection. ASL homeostasis can be studied by measuring ASL height in primary epithelial cultures from murine and human airways. The height can be determined using confocal fluoresce…

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A Seyhan Agircan, M Lampe, J Duerr, R Pepperkok, MA Mall (2015) Development of Confocal Reflection Microscopy for the Study of Airway Surface Liquid Dysregulation in Cystic Fibrosis. Pneumologie (07). https://doi.org/10.1055/s-0035-1556607

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