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Visualization of channel-activating protease (CAP) activity by peptide-based FRET probes

V Rickert-Zacharias, MA Mall, C Schultz · Pneumologie · Ausgabe 07/2015

DOI 10.1055/s-0035-1556608

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Autor:innenV Rickert-Zacharias, MA Mall, C Schultz
ZeitschriftPneumologie
Ausgabe07/2015
Jahrgang / SeitenNicht angegeben

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Abstract-Vorschau

Introduction: The epithelial sodium channel (ENaC) plays a crucial role in sodium transport across epithelial membranes and in the homeostasis of airway surface liquid (ASL) hydration. Proteolytic cleavage of the ENaC γ-subunit by channel-activating proteases (CAPs) increases the opening probability of the channel and thereby enhances sodium transport. Tarran and co-workers have shown that CAP expression is elevated…

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Zitierempfehlung

V Rickert-Zacharias, MA Mall, C Schultz (2015) Visualization of channel-activating protease (CAP) activity by peptide-based FRET probes. Pneumologie (07). https://doi.org/10.1055/s-0035-1556608

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