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β-Nicotinamide adenine dinucleotide: a novel bronchodilator inducing increase in intracellular cAMP

I Jurastow, S Engel, S Wiegand, A Rafiq, A Zakrzewicz, V Grau, C Nassenstein, M Bünemann, W Kummer · Pneumologie · Ausgabe 07/2015

DOI 10.1055/s-0035-1556611

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Autor:innenI Jurastow, S Engel, S Wiegand, A Rafiq, A Zakrzewicz, V Grau, C Nassenstein, M Bünemann, W Kummer
ZeitschriftPneumologie
Ausgabe07/2015
Jahrgang / SeitenNicht angegeben

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Abstract-Vorschau

Introduction: β-Nicotinamide adenine dinucleotide (β-NAD) has been reported to relax vascular and intestinal smooth muscle via purinergic P2Y1 and P2Y11 receptors, and we recently demonstrated its relaxing activity on murine and human airway smooth muscle. This bronchodilator activity, however, was independent from purinergic receptors, and occurred concomitantly with increases in intracellular calcium concentration…

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I Jurastow, S Engel, S Wiegand, A Rafiq, A Zakrzewicz, V Grau, C Nassenstein, M Bünemann, W Kummer (2015) β-Nicotinamide adenine dinucleotide: a novel bronchodilator inducing increase in intracellular cAMP. Pneumologie (07). https://doi.org/10.1055/s-0035-1556611

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