CareLit · DOI-Nachweis · Pneumologie
SLPI suppresses ATP-mediated release of IL-1β from human monocytes – evidence for a novel anti-inflammatory mechanism
DOI 10.1055/s-0035-1556628
Bibliografische Angaben
Nachweis in CareLit
Autor:innenA Zakrzewicz, S Wilker, S Janciauskiene, R Tikkanen, W Padberg, V Grau
ZeitschriftPneumologie
Ausgabe07/2015
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
Background: IL-1β is a multifunctional pro-inflammatory cytokine associated with diverse inflammatory disorders. IL-1β release requires two consecutive danger signals. LPS is a prototypical first signal inducing pro-IL-1β synthesis, whereas extracellular ATP is a typical second signal triggering inflammasome activation, proteolytic cleavage of pro-IL-1β by activated caspase-1, and release of mature IL-1β. Secretory…
Zitieren
Zitierempfehlung
A Zakrzewicz, S Wilker, S Janciauskiene, R Tikkanen, W Padberg, V Grau (2015) SLPI suppresses ATP-mediated release of IL-1β from human monocytes – evidence for a novel anti-inflammatory mechanism. Pneumologie (07). https://doi.org/10.1055/s-0035-1556628
Mit CareLit weiterarbeiten