CareLit · DOI-Nachweis · Pneumologie
Alpha-1 antitrypsin inhibits ATP-induced release of IL-1β in human monocytes via a cholinergic pathway
DOI 10.1055/s-0035-1556630
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Nachweis in CareLit
Autor:innenR Siebers, S Wilker, M Küllmar, N Aggarwal, A Zakrzewicz, W Padberg, S Janciauskiene, V Grau
ZeitschriftPneumologie
Ausgabe07/2015
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
Introduction: In human monocytes, activation of the P2X7 receptor leads to inflammasome assembly and activation of caspase 1 (casp-1). Active casp-1 can cleave pro-IL-1β, which then leads to release of IL-1β, an important mediator of inflammation. Alpha-1 antitrypsin (AAT), a major antiprotease of the lung, exerts anti-inflammatory functions via poorly defined pathways. We hypothesize that AAT inhibits inflammasome-…
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Zitierempfehlung
R Siebers, S Wilker, M Küllmar, N Aggarwal, A Zakrzewicz, W Padberg, S Janciauskiene, V Grau (2015) Alpha-1 antitrypsin inhibits ATP-induced release of IL-1β in human monocytes via a cholinergic pathway. Pneumologie (07). https://doi.org/10.1055/s-0035-1556630
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