CareLit · DOI-Nachweis · Pneumologie
Surfactant inhibits ATP-induced release of interleukin-1β in human monocytes.
DOI 10.1055/s-0035-1556631
Bibliografische Angaben
Nachweis in CareLit
Autor:innenS Backhaus, S Wilker, A Zakrzewicz, M Küllmar, W Padberg, C Ruppert, V Grau
ZeitschriftPneumologie
Ausgabe07/2015
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
Background: Interleukin-1β (IL-1β) is a pro-inflammatory cytokine involved in host defense. However, IL-1β importantly contributes to acute lung injury. In response to a first danger signal such as lipopolysaccharide, pro-IL-1β is synthesized by mononuclear phagocytes. Extracellular ATP is a prototypical second signal, which results in inflammasome activation, proteolytic cleavage and release of IL-1β. In contrast t…
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Zitierempfehlung
S Backhaus, S Wilker, A Zakrzewicz, M Küllmar, W Padberg, C Ruppert, V Grau (2015) Surfactant inhibits ATP-induced release of interleukin-1β in human monocytes. Pneumologie (07). https://doi.org/10.1055/s-0035-1556631
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