CareLit · DOI-Nachweis · Pneumologie
Inhibition of profibrotic signaling in fibroblasts from patients with IPF by the pan-histone deacetylase-inhibitor LBH589 or the IPF drug pirfenidone
DOI 10.1055/s-0035-1556650
Bibliografische Angaben
Nachweis in CareLit
Autor:innenM Korfei, S Skwarna, D Stelmaszek, I Henneke, BA MacKenzie, S Saito, C Ruppert, P Mahavadi, W Klepetko, S Bellusci, B Crestani, L Fink, W Seeger, OH Krämer, A Guenther
ZeitschriftPneumologie
Ausgabe07/2015
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
Introduction: Idiopathic pulmonary fibrosis (IPF) is a fatal disease characterized by distorted pulmonary structure and the excessive deposition of extracellular matrix (ECM) proteins, such as collagen. Myofibroblasts are the primary collagen-producing cells in IPF lungs, and their accumulation within lesions called fibroblast foci (FF) is a hallmark of IPF. We investigated the therapeutic potential of pan-histone d…
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Zitierempfehlung
M Korfei, S Skwarna, D Stelmaszek, I Henneke, BA MacKenzie, S Saito, C Ruppert, P Mahavadi, W Klepetko, S Bellusci, B Crestani, L Fink, W Seeger, OH Krämer, A Guenther (2015) Inhibition of profibrotic signaling in fibroblasts from patients with IPF by the pan-histone deacetylase-inhibitor LBH589 or the IPF drug pirfenidone. Pneumologie (07). https://doi.org/10.1055/s-0035-1556650
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