CareLit · DOI-Nachweis · Pneumologie
Disruption of the hepcidin/ferroportin regulatory circuitry causes increased pulmonary iron content and restrictive lung disease
DOI 10.1055/s-0035-1556652
Bibliografische Angaben
Nachweis in CareLit
Autor:innenJ Neves, M Costa da Silva, D Leitz, R Agrawal, MA Mall, S Altamura, MU Muckenthaler
ZeitschriftPneumologie
Ausgabe07/2015
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
All cell types of the lung, including airways, parenchyma and inflammatory cells need iron for metabolic processes. However, they must prevent iron overload which causes cellular damage due to the generation of reactive oxygen species (ROS). The risk for oxidative damage in the lung is exacerbated by its continuous exposure to high oxygen levels making iron detoxification within airway epithelial cells and alveolar…
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Zitierempfehlung
J Neves, M Costa da Silva, D Leitz, R Agrawal, MA Mall, S Altamura, MU Muckenthaler (2015) Disruption of the hepcidin/ferroportin regulatory circuitry causes increased pulmonary iron content and restrictive lung disease. Pneumologie (07). https://doi.org/10.1055/s-0035-1556652
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