CareLit · DOI-Nachweis · Zeitschrift für Gastroenterologie
Vitamin A derivatives regulate fibroblast growth factor 19 expression in human enterocytes
DOI 10.1055/s-0035-1558901
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Autor:innenD Jahn, D Sutor, J Schmitt, HM Hermanns, A Geier
ZeitschriftZeitschrift für Gastroenterologie
Ausgabe09/2015
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
Background: Human Fibroblast Growth Factor 19 (FGF19) and its mouse ortholog Fgf15 are gut-derived hormones with broad impact on bile acid (BA) and energy metabolism. FGF15/19 expression is induced by BA-mediated activation of the nuclear receptor (NR) FXR. Moreover, vitamin A (VA) has been shown to activate Fgf15 in an FXR/RXR-dependent manner in mice. Whether and how VA regulates FGF19 in humans is, however, curre…
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Zitierempfehlung
D Jahn, D Sutor, J Schmitt, HM Hermanns, A Geier (2015) Vitamin A derivatives regulate fibroblast growth factor 19 expression in human enterocytes. Zeitschrift für Gastroenterologie (09). https://doi.org/10.1055/s-0035-1558901
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