CareLit · DOI-Nachweis · Zeitschrift für Gastroenterologie
A kinome wide CRISPR/Cas9 screen uncovers novel resistance factors to MEK inhibition in colorectal cancer
DOI 10.1055/s-0035-1559220
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Nachweis in CareLit
Autor:innenT Zhan, D Brüggemann, F Heigwer, M Breinig, J Winter, S Leible, M Ebert, M Boutros
ZeitschriftZeitschrift für Gastroenterologie
Ausgabe08/2015
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
Einleitung: The Ras/MEK/ERK pathway is frequently mutated in colorectal cancer (CRC) and KRAS mutations present a major therapeutic challenge. Attempts to inhibit downstream effectors of KRAS including MEK revealed only modest clinical efficiency. The mechanisms by which CRC with KRAS mutation acquires resistance to MEK inhibition are not completely understood. Pooled CRISPR/Cas9 screens offer a novel high-throughpu…
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Zitierempfehlung
T Zhan, D Brüggemann, F Heigwer, M Breinig, J Winter, S Leible, M Ebert, M Boutros (2015) A kinome wide CRISPR/Cas9 screen uncovers novel resistance factors to MEK inhibition in colorectal cancer. Zeitschrift für Gastroenterologie (08). https://doi.org/10.1055/s-0035-1559220
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