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Cofilin-1-mediated growth regulation in pancreatic cancer cells is associated with downregulation of Gli1 and increased activity of the MAL/SRF transcription factor complex

B Kaistha, S Kirchhoff, H Schmidt, M Lauth, R Singh, B Sipos, T Gress, M Buchholz · Zeitschrift für Gastroenterologie · Ausgabe 08/2015

DOI 10.1055/s-0035-1559256

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Autor:innenB Kaistha, S Kirchhoff, H Schmidt, M Lauth, R Singh, B Sipos, T Gress, M Buchholz
ZeitschriftZeitschrift für Gastroenterologie
Ausgabe08/2015
Jahrgang / SeitenNicht angegeben

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Abstract-Vorschau

Introduction: We have previously described a multi-step high-content screening approach to identify novel functionally relevant target genes in pancreatic ductal adenocarcinoma (Buchholz et al., PLoS-One, in press). The results of these analyses predicted an unexpected and previously undocumented role for the small actin-binding protein cofilin-1 in growth control of pancreatic cancer cells. Methods: Multiple tissue…

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B Kaistha, S Kirchhoff, H Schmidt, M Lauth, R Singh, B Sipos, T Gress, M Buchholz (2015) Cofilin-1-mediated growth regulation in pancreatic cancer cells is associated with downregulation of Gli1 and increased activity of the MAL/SRF transcription factor complex. Zeitschrift für Gastroenterologie (08). https://doi.org/10.1055/s-0035-1559256

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