CareLit · DOI-Nachweis · Klinische Pädiatrie
Preclinical model development for pilocytic astrocytoma
DOI 10.1055/s-0035-1564679
Bibliografische Angaben
Nachweis in CareLit
Autor:innenF Selt, J Kiss, J Gronych, DTW Jones, T Brummer, AE Kulozik, SM Pfister, T Milde, O Witt
ZeitschriftKlinische Pädiatrie
Ausgabe11/2015
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
Pilocytic astrocytoma (PA), the most frequent pediatric brain tumor, exhibits an activation of MAPK-signaling by genetic aberration in nearly 100% of cases, with activating KIAA1549:BRAF-fusions being the most frequent alteration of this pathway (60 – 80%). Dealing with a single-pathway disease evokes hope for improvement of PA treatment by small molecule inhibitors of the MAPK-signalling pathway. However, faithful…
Zitieren
Zitierempfehlung
F Selt, J Kiss, J Gronych, DTW Jones, T Brummer, AE Kulozik, SM Pfister, T Milde, O Witt (2015) Preclinical model development for pilocytic astrocytoma. Klinische Pädiatrie (11). https://doi.org/10.1055/s-0035-1564679
Mit CareLit weiterarbeiten