CareLit · DOI-Nachweis · Zeitschrift für Gastroenterologie
A computational multi-scale model for the integration of paracrine stimuli activating NF-kB signalling in hepatocytes after lipopolysaccharide (LPS) treatment
DOI 10.1055/s-0035-1567934
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Nachweis in CareLit
Autor:innenK Beuke, F Schildberg, F Pinna, U Albrecht, R Liebe, M Bissinger, P Schirmacher, S Dooley, J Bode, P Knolle, U Kummer, S Sahle, K Breuhahn
ZeitschriftZeitschrift für Gastroenterologie
Ausgabe12/2015
Jahrgang / SeitenNicht angegeben
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Abstract-Vorschau
Background: Bacterial lipopolysaccharide (LPS) efficiently stimulates the secretion of tumor necrosis factor (TNF)-α from non-parenchymal Kupffer cells (KCs), liver sinusoidal endothelial cells (LSECs), and hepatic stellate cells (HSCs). Paracrine-acting TNFα subsequently activates the canonical NF-kB pathway in hepatocytes, which is a central regulator of acute phase protein expression and the inflammatory response…
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Zitierempfehlung
K Beuke, F Schildberg, F Pinna, U Albrecht, R Liebe, M Bissinger, P Schirmacher, S Dooley, J Bode, P Knolle, U Kummer, S Sahle, K Breuhahn (2015) A computational multi-scale model for the integration of paracrine stimuli activating NF-kB signalling in hepatocytes after lipopolysaccharide (LPS) treatment. Zeitschrift für Gastroenterologie (12). https://doi.org/10.1055/s-0035-1567934
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