CareLit · DOI-Nachweis · Zeitschrift für Gastroenterologie
A human hepatic in vitro co-culture system for the analysis of DILI related signaling
DOI 10.1055/s-0035-1567936
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Autor:innenF Wewering, F Jouy, DKWK Wissenbach, S Gebauer, M von Bergen, A Luch, S Kalkhof, S Zellmer
ZeitschriftZeitschrift für Gastroenterologie
Ausgabe12/2015
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
The interaction between immune cells and hepatocytes during a sterile inflammation has come into focus in Drug-Induced Liver Injury (DILI) research during recent years. Therefore, this crosstalk was analysed in a novel indirect co-culture system with HepG2 and differentiated THP-1 cells using the antifungal drug ketoconazole as a known hepatotoxic model compound. The metabolism of ketoconazole, changes in the proteo…
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Zitierempfehlung
F Wewering, F Jouy, DKWK Wissenbach, S Gebauer, M von Bergen, A Luch, S Kalkhof, S Zellmer (2015) A human hepatic in vitro co-culture system for the analysis of DILI related signaling. Zeitschrift für Gastroenterologie (12). https://doi.org/10.1055/s-0035-1567936
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