CareLit · DOI-Nachweis · Zeitschrift für Gastroenterologie
Differential activation of RhoA and c-SRC in experimental and human fibrosis
DOI 10.1055/s-0035-1567946
Bibliografische Angaben
Nachweis in CareLit
Autor:innenJ Görtzen, J Bierwolf, S Klein, R Schierwagen, CP Strassburg, W Laleman, JM Pollok, RG Wells, J Trebicka
ZeitschriftZeitschrift für Gastroenterologie
Ausgabe12/2015
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
Introduction: RhoA orchestrates cytoskeleton formation, migration and mobility via c-SRC and mDia1 in different cells. RhoA/ROCK also plays a crucial role in hepatic stellate cells and hepatic fibrogenesis. Matrix stiffness promotes HSC activation via cytoskeleton modulation. The role of SRC and mDia1 in HSC, and the role of matrix stiffness, were investigated in this study. Methods: Liver fibrosis was induced in ra…
Zitieren
Zitierempfehlung
J Görtzen, J Bierwolf, S Klein, R Schierwagen, CP Strassburg, W Laleman, JM Pollok, RG Wells, J Trebicka (2015) Differential activation of RhoA and c-SRC in experimental and human fibrosis. Zeitschrift für Gastroenterologie (12). https://doi.org/10.1055/s-0035-1567946
Mit CareLit weiterarbeiten