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LPS and bone morphogenetic protein (BMP)-9 regulate the hepatocytes acute phase response by affecting hepatic stellate cells

R Liebe, C Meyer, S Chen, F Wan, K Abramovic, A Müller, H Gaitantzi, C König, H Augustin, M Ebert, S Dooley, K Breitkopf-Heinlein · Zeitschrift für Gastroenterologie · Ausgabe 12/2015

DOI 10.1055/s-0035-1567959

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Autor:innenR Liebe, C Meyer, S Chen, F Wan, K Abramovic, A Müller, H Gaitantzi, C König, H Augustin, M Ebert, S Dooley, K Breitkopf-Heinlein
ZeitschriftZeitschrift für Gastroenterologie
Ausgabe12/2015
Jahrgang / SeitenNicht angegeben

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Abstract-Vorschau

Under conditions of liver damage (bacterial overgrowth in the gut but also damage induced by CCl4 injection or during regeneration after partial hepatectomy), LPS levels are elevated and lead to induction of the inflammatory response (= acute phase response; APR) in hepatocytes. BMP-9, a member of the TGF-β family of cytokines, is produced in the liver and we found that it has rather maturation inducing effects ther…

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Zitierempfehlung

R Liebe, C Meyer, S Chen, F Wan, K Abramovic, A Müller, H Gaitantzi, C König, H Augustin, M Ebert, S Dooley, K Breitkopf-Heinlein (2015) LPS and bone morphogenetic protein (BMP)-9 regulate the hepatocytes acute phase response by affecting hepatic stellate cells. Zeitschrift für Gastroenterologie (12). https://doi.org/10.1055/s-0035-1567959

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