CareLit · DOI-Nachweis · Zeitschrift für Gastroenterologie
Regulation and profibrogenic effects of TGF-β1 signaling in mast cells, a cell type contributing to the outcome of hepatic injury
DOI 10.1055/s-0035-1567961
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Autor:innenM Neß, JM Bangen, M Huber, C Liedtke, R Weiskirchen, SK Meurer
ZeitschriftZeitschrift für Gastroenterologie
Ausgabe12/2015
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
Background: In the setting of mastocytosis, mast cells have been shown to promote renal and lung fibrosis, whereas their effect in the liver is under debate [1 – 4]. Mast cell effects are based on the secretion of mitogenic and profibrotic, e.g. TGF-β1, cytokines – leading to activation and proliferation of fibroblasts [5] – and proteases – causing a direct or indirect modulation of extracellular matrix homeostasis…
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Zitierempfehlung
M Neß, JM Bangen, M Huber, C Liedtke, R Weiskirchen, SK Meurer (2015) Regulation and profibrogenic effects of TGF-β1 signaling in mast cells, a cell type contributing to the outcome of hepatic injury. Zeitschrift für Gastroenterologie (12). https://doi.org/10.1055/s-0035-1567961
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