CareLit · DOI-Nachweis · Zeitschrift für Gastroenterologie
Overwhelming high quantities of the matricellular protein CCN1/CYR61 induce ER stress-related cellular apoptosis in hepatic stellate cells
DOI 10.1055/s-0035-1567962
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Autor:innenE Borkham-Kamphorst, BT Steffen, E Van de Leur, U Haas, L Tihaa, R Weiskirchen
ZeitschriftZeitschrift für Gastroenterologie
Ausgabe12/2015
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
Background: CCN1/CYR61 is a matricellular protein belonging to CCN protein family that contains six secreted proteins associated with extracellular matrix signaling [1]. It acts as an enhancer of cutaneous wound healing process by preventing hypertrophic scar formation through induction of myofibroblast (MFB) senescence [2]. In liver fibrosis, senescent cells are primarily derived from activated hepatic stellate cel…
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Zitierempfehlung
E Borkham-Kamphorst, BT Steffen, E Van de Leur, U Haas, L Tihaa, R Weiskirchen (2015) Overwhelming high quantities of the matricellular protein CCN1/CYR61 induce ER stress-related cellular apoptosis in hepatic stellate cells. Zeitschrift für Gastroenterologie (12). https://doi.org/10.1055/s-0035-1567962
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