CareLit · DOI-Nachweis · Zeitschrift für Gastroenterologie
The TGR5 protein amount is reduced in patients with primary sclerosing cholangitis (PSC)
DOI 10.1055/s-0035-1567969
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Autor:innenL Spomer, J Höhne, J Hov, T Karlsen, D Nierhoff, D Häussinger, V Keitel
ZeitschriftZeitschrift für Gastroenterologie
Ausgabe12/2015
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
Introduction: The localization of TGR5 in cholangiocytes, the choleretic, anti-inflammatory and anti-apoptotic functions of the receptor suggest that TGR5 is important for the pathogenesis of biliary diseases. Additionally, for the biliary tract disease PSC an association with the frequent TGR5 exon 1 SNP rs11554825 is described, which appears with a lower TGR5 mRNA expression (measured in lymphoblastic cell line) (…
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Zitierempfehlung
L Spomer, J Höhne, J Hov, T Karlsen, D Nierhoff, D Häussinger, V Keitel (2015) The TGR5 protein amount is reduced in patients with primary sclerosing cholangitis (PSC). Zeitschrift für Gastroenterologie (12). https://doi.org/10.1055/s-0035-1567969
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