CareLit · DOI-Nachweis · Zeitschrift für Gastroenterologie
Binding Mode Prediction and Validation of Bile Acid and Neurosteroid Agonists of TGR5
DOI 10.1055/s-0035-1567980
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Autor:innenCGW Gertzen, L Spomer, D Häussinger, V Keitel, H Gohlke
ZeitschriftZeitschrift für Gastroenterologie
Ausgabe12/2015
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
TGR5 is the first bile acid sensing G-protein coupled bile acid receptor (GPCR) GPCR and directly interacts with several G-protein subtypes [1]. High expression levels of TGR5 are found in the brain, the liver, and the gastrointestinal tract. TGR5 is an emerging target for the treatment of metabolic diseases [2 – 4]. Therefore, developing selective and potent agonists of TGR5 is of high importance [5]. However, with…
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Zitierempfehlung
CGW Gertzen, L Spomer, D Häussinger, V Keitel, H Gohlke (2015) Binding Mode Prediction and Validation of Bile Acid and Neurosteroid Agonists of TGR5. Zeitschrift für Gastroenterologie (12). https://doi.org/10.1055/s-0035-1567980
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