CareLit · DOI-Nachweis · Zeitschrift für Gastroenterologie
Combined effects of the prosteatotic TM6SF2 and PNPLA3 variants on severity of NALFD: multicentre biopsy-based study in German patients
DOI 10.1055/s-0035-1567983
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Autor:innenM Krawczyk, M Rau, J Schattenberg, H Bantel, A Pathil, M Demir, J Kluwe, T Böttler, F Lammert, A Geier
ZeitschriftZeitschrift für Gastroenterologie
Ausgabe12/2015
Jahrgang / SeitenNicht angegeben
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Abstract-Vorschau
Introduction: The PNPLA3 (adiponutrin) mutation p.I148 M represents the common genetic risk factor for (non-)alcoholic fatty liver disease (NAFLD) and progressive liver fibrosis. Lately a second prosteatotic variant, TM6SF2 p.E167K, has been detected (Nat Genet 2014). So far it remains unclear if this mutation, alike the PNPLA3 p.I148 M variant, increases the risk of liver fibrosis. In the current project we analyse…
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Zitierempfehlung
M Krawczyk, M Rau, J Schattenberg, H Bantel, A Pathil, M Demir, J Kluwe, T Böttler, F Lammert, A Geier (2015) Combined effects of the prosteatotic TM6SF2 and PNPLA3 variants on severity of NALFD: multicentre biopsy-based study in German patients. Zeitschrift für Gastroenterologie (12). https://doi.org/10.1055/s-0035-1567983
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