CareLit · DOI-Nachweis · Zeitschrift für Gastroenterologie
Delayed intrahepatic cholestasis induced by anabolic steroids in a patient with haploinsufficiency of the pregnane X receptor (PXR/NR1I2)
DOI 10.1055/s-0035-1568031
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Autor:innenR Liebe, M Krawczyk, J Raszeja-Wyszomirska, B Kruk, R Preis, J Trottier, O Barbier, P Milkiewicz, F Lammert
ZeitschriftZeitschrift für Gastroenterologie
Ausgabe12/2015
Jahrgang / SeitenNicht angegeben
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Abstract-Vorschau
Case description: We describe a 32 year old male patient who developed cholestatic liver injury two weeks after a 2-month course of anabolic steroids. Methods and results: Next generation sequencing of a panel of 24 cholestasis-related genes revealed a heterozygous 2 basepair deletion in exon 1 of the pregnane X receptor (PCR/NR1I2) gene. Analysis of serum bile salts revealed marked imbalances, strongly resembling t…
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Zitierempfehlung
R Liebe, M Krawczyk, J Raszeja-Wyszomirska, B Kruk, R Preis, J Trottier, O Barbier, P Milkiewicz, F Lammert (2015) Delayed intrahepatic cholestasis induced by anabolic steroids in a patient with haploinsufficiency of the pregnane X receptor (PXR/NR1I2). Zeitschrift für Gastroenterologie (12). https://doi.org/10.1055/s-0035-1568031
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