CareLit · DOI-Nachweis · Zeitschrift für Gastroenterologie
Accumulation of hepatitis B surface antigen promotes the development of alpha-1 antitrypsin mutation-related liver disease
DOI 10.1055/s-0035-1568064
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Nachweis in CareLit
Autor:innenD Kuscuoglu, GK Ensari, K Hittatiya, HP Fischer, C Trautwein, P Strnad
ZeitschriftZeitschrift für Gastroenterologie
Ausgabe12/2015
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
Introduction: α1-antitrypsin (AAT) constitutes the major serum protease inhibitor that is produced predominantly in hepatocytes. An AAT mutation termed PiZ leads to its polymerization and retention in the endoplasmic reticulum (ER) thereby causing the development of AAT deficiency, the third most common lethal genetic condition in humans. While up to 40% of PiZZ patients develop liver cirrhosis, the phenotype of the…
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Zitierempfehlung
D Kuscuoglu, GK Ensari, K Hittatiya, HP Fischer, C Trautwein, P Strnad (2015) Accumulation of hepatitis B surface antigen promotes the development of alpha-1 antitrypsin mutation-related liver disease. Zeitschrift für Gastroenterologie (12). https://doi.org/10.1055/s-0035-1568064
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