CareLit · DOI-Nachweis · Zeitschrift für Gastroenterologie
Autophagy impairment and ERK and p38 activation are central mediators of irinotecan-induced steatohepatitis
DOI 10.1055/s-0035-1568069
Bibliografische Angaben
Nachweis in CareLit
Autor:innenA Mahli, M Saugspier, S Lee, WE Thasler, M Müller, C Hellerbrand
ZeitschriftZeitschrift für Gastroenterologie
Ausgabe12/2015
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
Treatment with irinotecan is associated with the development of chemotherapy-associated steatohepatitis (CASH), which significantly increases the risk of perioperative morbidity and mortality. The aim of this study was to unravel the molecular mechanisms of this phenomenon. Methods: Mechanisms of irinotecan induced steatohepatitis were studied in primary human hepatocytes in vitro, irinotecan treated mice and liver…
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Zitierempfehlung
A Mahli, M Saugspier, S Lee, WE Thasler, M Müller, C Hellerbrand (2015) Autophagy impairment and ERK and p38 activation are central mediators of irinotecan-induced steatohepatitis. Zeitschrift für Gastroenterologie (12). https://doi.org/10.1055/s-0035-1568069
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