CareLit · DOI-Nachweis · Zeitschrift für Gastroenterologie
Different oncogenic potential in the mouse liver of mutant forms of the p110alpha catalytic subunit of phosphoinositide-3-kinase (PIK3CA)
DOI 10.1055/s-0035-1568072
Bibliografische Angaben
Nachweis in CareLit
Autor:innenK Annweiler, K Evert, A Cigliano, M Sini, G Latte, M Frau, RM Pascale, F Dombrowski, DF Calvisi, M Evert, K Utpatel
ZeitschriftZeitschrift für Gastroenterologie
Ausgabe12/2015
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
Background: PIK3CA, encoding the catalytic subunit p110α of class I phosphoinositide-3-kinase (PI3K), is mutated or overexpressed in many tumors, including hepatocellular carcinoma (HCC), where it is supposed to act as an oncogene. Here, we developed new mouse models to investigate the oncogenic effects of gain-of-function PIK3CA mutations and identified downstream PI3K signaling components in the mouse liver. Metho…
Zitieren
Zitierempfehlung
K Annweiler, K Evert, A Cigliano, M Sini, G Latte, M Frau, RM Pascale, F Dombrowski, DF Calvisi, M Evert, K Utpatel (2015) Different oncogenic potential in the mouse liver of mutant forms of the p110alpha catalytic subunit of phosphoinositide-3-kinase (PIK3CA). Zeitschrift für Gastroenterologie (12). https://doi.org/10.1055/s-0035-1568072
Mit CareLit weiterarbeiten