CareLit · DOI-Nachweis · Zeitschrift für Gastroenterologie
Inactivation of fatty acid synthase impairs hepatocarcinogenesis driven by AKT in mice
DOI 10.1055/s-0035-1568081
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Autor:innenDF Calvisi, L Li, GM Pilo, A Cigliano, S Ribback, F Dombrowski, X Chen, M Evert
ZeitschriftZeitschrift für Gastroenterologie
Ausgabe12/2015
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
Background: Cumulating evidence underlines the crucial role of aberrant lipid biosyntesis in human hepatocellular carcinoma (HCC). Here, we investigated the oncogenic potential of fatty acid synthase (FASN), the master regulator of de novo lipogenesis, in the mouse liver. Methods: FASN was overexpressed in the mouse liver, either alone or in combination with activated N-Ras, c-Met, or SCD1, via hydrodynamic injectio…
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Zitierempfehlung
DF Calvisi, L Li, GM Pilo, A Cigliano, S Ribback, F Dombrowski, X Chen, M Evert (2015) Inactivation of fatty acid synthase impairs hepatocarcinogenesis driven by AKT in mice. Zeitschrift für Gastroenterologie (12). https://doi.org/10.1055/s-0035-1568081
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