CareLit · DOI-Nachweis · Zeitschrift für Gastroenterologie
CRISPR/Cas9 “double”-nickase mediated inactivation of hepatitis B virus replication
DOI 10.1055/s-0035-1568102
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Nachweis in CareLit
Autor:innenM Karimova, N Beschorner, W Dammermann, J Chemnitz, D Indenbirken, A Grundhoff, S Lüth, F Buchholz, J Schulze zur Wiesch, J Hauber
ZeitschriftZeitschrift für Gastroenterologie
Ausgabe12/2015
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
Background: Current antiviral therapies cannot cure hepatitis B virus (HBV) infection, since successful HBV eradication would require the inactivation of the viral genome, which primarily persists in host cells as episomal covalently closed circular DNA (cccDNA) and, to a lesser extent, as chromosomally integrated sequences. However, novel designer-enzymes, such as the CRISPR/Cas9 RNA-guided nuclease system, provide…
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Zitierempfehlung
M Karimova, N Beschorner, W Dammermann, J Chemnitz, D Indenbirken, A Grundhoff, S Lüth, F Buchholz, J Schulze zur Wiesch, J Hauber (2015) CRISPR/Cas9 “double”-nickase mediated inactivation of hepatitis B virus replication. Zeitschrift für Gastroenterologie (12). https://doi.org/10.1055/s-0035-1568102
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