CareLit · DOI-Nachweis · Diabetologie und Stoffwechsel
KATP channel-dependent and -independent protection against glucolipotoxicity-induced damage of mouse beta-cells
DOI 10.1055/s-0036-1580759
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Autor:innenG Drews, R Wagner, M Düfer, P Krippeit-Drews
ZeitschriftDiabetologie und Stoffwechsel
Ausgabe04/2016
Jahrgang / SeitenNicht angegeben
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Abstract-Vorschau
Background: Obesity leads to oxidative stress and glucolipotoxicity (Gltx) which affect the metabolic integrity of beta-cells. The present work aimed to clarify whether genetic and pharmacological deletion of functional KATP channels prevents Gltx-induced metabolic damage as shown before for oxidative stress. Methods: Beta-cells from WT and SUR1-KO mice were kept in Gltx medium (30 mM glucose, 1 mM palmitate) for 1…
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Zitierempfehlung
G Drews, R Wagner, M Düfer, P Krippeit-Drews (2016) KATP channel-dependent and -independent protection against glucolipotoxicity-induced damage of mouse beta-cells. Diabetologie und Stoffwechsel (04). https://doi.org/10.1055/s-0036-1580759
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