CareLit · DOI-Nachweis · Diabetologie und Stoffwechsel
Role of FGF21 and GCN2 in mediating the metabolic response to dietary protein restriction
DOI 10.1055/s-0036-1580771
Bibliografische Angaben
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Autor:innenT Laeger, DC Albarado, L Trosclair, J Hedgepeth, CD Morrison
ZeitschriftDiabetologie und Stoffwechsel
Ausgabe04/2016
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
FGF21 is an endocrine signal of protein restriction (PR) and prior data implicate the General Control Nonderepressible 2 (GCN2) kinase as the amino acid sensor linking PR to FGF21 induction. Therefore, we hypothesized that GCN2-deficient mice would fail to respond to reduced dietary protein intake and consequently recapitulate the phenotype of FGF21-deficient mice. C57BL/6J mice (WT), FGF21- and GCN2-deficient mice…
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Zitierempfehlung
T Laeger, DC Albarado, L Trosclair, J Hedgepeth, CD Morrison (2016) Role of FGF21 and GCN2 in mediating the metabolic response to dietary protein restriction. Diabetologie und Stoffwechsel (04). https://doi.org/10.1055/s-0036-1580771
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