CareLit · DOI-Nachweis · Diabetologie und Stoffwechsel
Estrogen receptor alpha (ERα)-acylation induced by stearic acid leads to impaired E2-signaling in macrophages during high fat diet (HFD) feeding
DOI 10.1055/s-0036-1580812
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Autor:innenZ Ban, P Maurischat, V Benz, R Klopfleisch, A Sonnenburg, M Rothe, G Schuler, S Brix, A Foryst-Ludwig, U Kintscher
ZeitschriftDiabetologie und Stoffwechsel
Ausgabe04/2016
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
We previously encountered in a high-estradiol (E2)-animal model, the modulation of the immune response and the attenuation of ERα-signaling due to HFD-feeding, resulting in massive inflammatory processes. Identifying stearic acid (C18:0) as the fatty acid at highest induced by HFD (566.89 ± 25.63 vs. 982.57 ± 67.28 µg/ml), we investigated the effects of C18:0 on macrophages on an E2-background stimulation, using dif…
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Zitierempfehlung
Z Ban, P Maurischat, V Benz, R Klopfleisch, A Sonnenburg, M Rothe, G Schuler, S Brix, A Foryst-Ludwig, U Kintscher (2016) Estrogen receptor alpha (ERα)-acylation induced by stearic acid leads to impaired E2-signaling in macrophages during high fat diet (HFD) feeding. Diabetologie und Stoffwechsel (04). https://doi.org/10.1055/s-0036-1580812
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