CareLit · DOI-Nachweis · Diabetologie und Stoffwechsel
Fndc4, a highly identical ortholog of Irisin binds and activates a novel orphan receptor G-protein coupled receptor
DOI 10.1055/s-0036-1580814
Bibliografische Angaben
Nachweis in CareLit
Autor:innenA Georgiadi, X Ma, M Bosma, E Graham, O Shilkova, F Mattijssen, AA Khan, JCA Higareda, T Wünsch, M Johansson, S Seaman, BS Croix, O Ritvos, N Nakamura, S Hirose, M Scheideler, S Herzig, PA Böstrom
ZeitschriftDiabetologie und Stoffwechsel
Ausgabe04/2016
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
Aim: Irisin, encoded by the Fndc5 gene, was identified as an exercise-induced, secreted protein promoting beige cell formation. Here we explore Fndc4, a highly identical ortholog of Fndc5. Fndc4 is proteolytically cleaved, to release an extracellular polypeptide, which we named Irisin2. Methods: In order to investigate the biological effects of Irisin2 we manufactured a stable recombinant Irisin2 and used it in a fl…
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Zitierempfehlung
A Georgiadi, X Ma, M Bosma, E Graham, O Shilkova, F Mattijssen, AA Khan, JCA Higareda, T Wünsch, M Johansson, S Seaman, BS Croix, O Ritvos, N Nakamura, S Hirose, M Scheideler, S Herzig, PA Böstrom (2016) Fndc4, a highly identical ortholog of Irisin binds and activates a novel orphan receptor G-protein coupled receptor. Diabetologie und Stoffwechsel (04). https://doi.org/10.1055/s-0036-1580814
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