CareLit · DOI-Nachweis · Diabetologie und Stoffwechsel
Pharmacological inhibition of nicotinamide N-methyltransferase (NNMT) in adipocytes by romidepsin
DOI 10.1055/s-0036-1580818
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Nachweis in CareLit
Autor:innenB Zapp, B Rudolphi, NA Kraus, J Klein, C Wanner, D Kraus
ZeitschriftDiabetologie und Stoffwechsel
Ausgabe04/2016
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
Background: Expression of nicotinamide N-methyltransferase (NNMT) is increased in adipose tissue in obesity. Fat-specific knockdown of NNMT with antisense oligonucleotides (ASO) prevents diet-induced obesity in mice. In cultured adipocytes however, transfection efficiency of ASO is poor. Romidepsin (depsipeptide) is a small molecule that suppresses NNMT expression in cultured thyroid cancer cells, but whose effects…
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Zitierempfehlung
B Zapp, B Rudolphi, NA Kraus, J Klein, C Wanner, D Kraus (2016) Pharmacological inhibition of nicotinamide N-methyltransferase (NNMT) in adipocytes by romidepsin. Diabetologie und Stoffwechsel (04). https://doi.org/10.1055/s-0036-1580818
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