CareLit · DOI-Nachweis · Diabetologie und Stoffwechsel
Impaired Pro-opiomelanocortin (Pomc) – Mu Opioid Receptor (MOR) axis contributes to painful diabetic neuropathy in Streptozotocin induced mice
DOI 10.1055/s-0036-1580825
Bibliografische Angaben
Nachweis in CareLit
Autor:innenDD Deshpande, TH Fleming, ROB Gans, PP Nawroth
ZeitschriftDiabetologie und Stoffwechsel
Ausgabe04/2016
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
Background: One-third of diabetic patients experience hyperalgesia and/or allodynia, however, current treatments are inefficient in reversing these symptoms and can have adverse side effects. It is known that the endogenous opioid system can modulate pain sensitivity. Pomc is cleaved to produce the opioid peptide β-endorphin, which binds to MOR resulting in alleviation of pain. This study examines the significance o…
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Zitierempfehlung
DD Deshpande, TH Fleming, ROB Gans, PP Nawroth (2016) Impaired Pro-opiomelanocortin (Pomc) – Mu Opioid Receptor (MOR) axis contributes to painful diabetic neuropathy in Streptozotocin induced mice. Diabetologie und Stoffwechsel (04). https://doi.org/10.1055/s-0036-1580825
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