CareLit · DOI-Nachweis · Diabetologie und Stoffwechsel
Angiotensin II type 2 receptor (AT2R) localizes to mitochondria of renal tubules and modifies mitochondrial function in early stages of type 1 diabetes in rats
DOI 10.1055/s-0036-1580893
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Autor:innenT Micakovic, M Papagiannarou, E Clark, N Volk, T Fleming, HJ Gröne, S Hoffmann
ZeitschriftDiabetologie und Stoffwechsel
Ausgabe04/2016
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
Background: Diabetic nephropathy (DN) is associated with mitochondrial dysfunction and increased activity of the local Renin-Angiotensin-System. Aim: This study aimed to verify the existence of mitochondrial AT2Rs and their role in DN. Methods: AT2Rs on mitochondria were demonstrated by immunohistochemistry using kidney sections of AT2R overexpressing transgenic rats (TGR) and AT2R-knockout mice and by receptor bind…
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Zitierempfehlung
T Micakovic, M Papagiannarou, E Clark, N Volk, T Fleming, HJ Gröne, S Hoffmann (2016) Angiotensin II type 2 receptor (AT2R) localizes to mitochondria of renal tubules and modifies mitochondrial function in early stages of type 1 diabetes in rats. Diabetologie und Stoffwechsel (04). https://doi.org/10.1055/s-0036-1580893
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