CareLit · DOI-Nachweis · Diabetologie und Stoffwechsel
Mesenchymal stem cell (MSC)-mediated activation of ERK1/2 signaling does not contribute to maintained survival of cocultured alloxan-treated INS-1E beta cells
DOI 10.1055/s-0036-1580894
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Autor:innenW Zhang, N Peradze, F Liu, J Straetener, K Laubner, N Perakakis, J Seufert, G Päth
ZeitschriftDiabetologie und Stoffwechsel
Ausgabe04/2016
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
Introduction: Injury-activated MSC secrete tissue protective factors which contribute to re-establishment of the local microenvironment. We previously demonstrated that cocultured telomerase-immortalised human MSC (hMSC-TERT) promote survival of alloxan (ALX)- or streptozotocin-treated INS-1E beta cells via AKT signalling. hMSC-TERT further mediated proliferation via ERK1/2 signalling. Here we investigated whether E…
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Zitierempfehlung
W Zhang, N Peradze, F Liu, J Straetener, K Laubner, N Perakakis, J Seufert, G Päth (2016) Mesenchymal stem cell (MSC)-mediated activation of ERK1/2 signaling does not contribute to maintained survival of cocultured alloxan-treated INS-1E beta cells. Diabetologie und Stoffwechsel (04). https://doi.org/10.1055/s-0036-1580894
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