CareLit · DOI-Nachweis · Diabetologie und Stoffwechsel
The genetic variant I148 M in PNPLA3 is associated with increased hepatic retinyl-palmitate storage in humans
DOI 10.1055/s-0036-1580902
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Nachweis in CareLit
Autor:innenM Kovarova, I Königsrainer, A Königsrainer, F Machicao, HU Häring, E Schleicher, A Peter
ZeitschriftDiabetologie und Stoffwechsel
Ausgabe04/2016
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
Context: Previous studies revealed that the common sequence variant I148 M in patatin-like phospholipase domain-containing protein 3 (PNPLA3) is associated with liver fat content and liver diseases, but not with insulin resistance. Recent data suggest that the PNPLA3 I148 M variant has reduced retinyl-palmitate lipase activity in hepatic stellate cells. Objective: We hypothesized that the PNPLA3 I148 M variant is as…
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Zitierempfehlung
M Kovarova, I Königsrainer, A Königsrainer, F Machicao, HU Häring, E Schleicher, A Peter (2016) The genetic variant I148 M in PNPLA3 is associated with increased hepatic retinyl-palmitate storage in humans. Diabetologie und Stoffwechsel (04). https://doi.org/10.1055/s-0036-1580902
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