CareLit · DOI-Nachweis · Klinische Pädiatrie
Nup98-Kdm5a, induced via CRISPR-Cas9 genome editing, transforms murine hematopoietic stem cells
DOI 10.1055/s-0036-1582483
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Nachweis in CareLit
Autor:innenLA Matthes, J Reimer, S Knoess, JH Klusmann, D Heckl
ZeitschriftKlinische Pädiatrie
Ausgabe05/2016
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
Introduction: Pediatric acute megakaryoblastic leukemia is characterized by unique recurrent chromosomal translocations (CTs) with NUP98-KDM 5A being one of the most frequent. However, adequat models to investigate the role of NUP98-KDM 5A in non-DS-AMKL are yet to be established. Methods: A lentiviral CRISPR-Cas9 vector containing two sgRNAs to generate the Nup98-Kdm5a translocation was generated and introduced int…
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Zitierempfehlung
LA Matthes, J Reimer, S Knoess, JH Klusmann, D Heckl (2016) Nup98-Kdm5a, induced via CRISPR-Cas9 genome editing, transforms murine hematopoietic stem cells. Klinische Pädiatrie (05). https://doi.org/10.1055/s-0036-1582483
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