CareLit · DOI-Nachweis · Klinische Pädiatrie
Aberrant transcriptional pathways in t(12;21) Acute Lymphoblastic Leukemia
DOI 10.1055/s-0036-1582489
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Autor:innenA Sundaresh, L Gasparoli, M Mangolini, D Edwards, M Hubank, T Brooks, J Bartram, N Goulden, P Ancliff, J de Boer, O Williams
ZeitschriftKlinische Pädiatrie
Ausgabe05/2016
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
Introduction: The single most frequent chromosomal translocation associated with childhood Acute Lymphoblastic Leukemia is the t(12;21) rearrangement that creates a fusion gene between TEL (ETV6) and AML1 (RUNX1). Although TEL-AML1+ patients have very good prognoses, relapses occur in up to 20% of patients and many patients face long-term side effects of chemotherapy. Recent data from our lab has shown that TEL-AML1…
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Zitierempfehlung
A Sundaresh, L Gasparoli, M Mangolini, D Edwards, M Hubank, T Brooks, J Bartram, N Goulden, P Ancliff, J de Boer, O Williams (2016) Aberrant transcriptional pathways in t(12;21) Acute Lymphoblastic Leukemia. Klinische Pädiatrie (05). https://doi.org/10.1055/s-0036-1582489
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