CareLit · DOI-Nachweis · Klinische Pädiatrie
Pre-BCR expression predicts sensitivity to SYK inhibition in B-cell acute lymphoblastic leukemia
DOI 10.1055/s-0036-1582492
Bibliografische Angaben
Nachweis in CareLit
Autor:innenS Köhrer, F Seyfried, KM Debatin, M Müschen, LH Meyer, RE Davis, JA Burger
ZeitschriftKlinische Pädiatrie
Ausgabe05/2016
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
Introduction: Recent studies have suggested SYK as target for the treatment of pre-BCR+ B-ALL but whether pre-BCR status constitutes the only predictor for sensitivity to SYK inhibition in B-ALL is discussed controversially. Methods: We employed a comparative approach of pre-BCR knockout and pharmacologic inhibition of pre-BCR signaling with SYK inhibitors to dissect the requirements for the SYK-dependent survival o…
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Zitierempfehlung
S Köhrer, F Seyfried, KM Debatin, M Müschen, LH Meyer, RE Davis, JA Burger (2016) Pre-BCR expression predicts sensitivity to SYK inhibition in B-cell acute lymphoblastic leukemia. Klinische Pädiatrie (05). https://doi.org/10.1055/s-0036-1582492
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