CareLit · DOI-Nachweis · Klinische Pädiatrie
Efficacy of the BH3-mimetic ABT-199 in acute lymphoblastic leukemia
DOI 10.1055/s-0036-1582495
Bibliografische Angaben
Nachweis in CareLit
Autor:innenR Hörl, F Seyfried, S Demir, J Zinngrebe, S Köhrer, KM Debatin, LH Meyer
ZeitschriftKlinische Pädiatrie
Ausgabe05/2016
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
Introduction: Acute lymphoblastic leukemia (ALL) cells can evade from apoptosis by upregulating anti-apoptotic proteins. Mcl-1 and Bcl-2 are frequently overexpressed in ALL, thus, appearing as promising targets for anti-ALL therapy. Methods: In vitro/ex vivo exposure of cell lines and primary patient-derived xenograft samples (pdx) to ABT-199, Dinaciclib and chemotherapy, assessment of cellular viability, generation…
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Zitierempfehlung
R Hörl, F Seyfried, S Demir, J Zinngrebe, S Köhrer, KM Debatin, LH Meyer (2016) Efficacy of the BH3-mimetic ABT-199 in acute lymphoblastic leukemia. Klinische Pädiatrie (05). https://doi.org/10.1055/s-0036-1582495
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