CareLit · DOI-Nachweis · Klinische Pädiatrie
Targeting mutant TP53 in ALL
DOI 10.1055/s-0036-1582498
Bibliografische Angaben
Nachweis in CareLit
Autor:innenS Demir, G Selivanova, E Tausch, L Wiesmüller, S Stilgenbauer, G te Kronnie, KM Debatin, LH Meyer
ZeitschriftKlinische Pädiatrie
Ausgabe05/2016
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
Introduction: In ALL, TP53 mutations (TP53mut) are increased at relapse and associated with poor prognosis and resistance. APR-246 binds to mutant p53 and restoring wt conformation. Methods: TP53mut were analyzed by dHPLC and Sanger sequencing, apoptosis by AnnexinV/PI, p53 targets by western blotting, p53 silencing by lentiviral shRNA, and phosphorylation by phosphoflow cytometry. Results: APR-246 exposure led to a…
Zitieren
Zitierempfehlung
S Demir, G Selivanova, E Tausch, L Wiesmüller, S Stilgenbauer, G te Kronnie, KM Debatin, LH Meyer (2016) Targeting mutant TP53 in ALL. Klinische Pädiatrie (05). https://doi.org/10.1055/s-0036-1582498
Mit CareLit weiterarbeiten