CareLit · DOI-Nachweis · Klinische Pädiatrie
CAR-engineered precursor T cells (preTs) for leukemia control after hematopoietic stem cell transplantation
DOI 10.1055/s-0036-1582500
Bibliografische Angaben
Nachweis in CareLit
Autor:innenM Maluski, J Herbst, MG Sauer
ZeitschriftKlinische Pädiatrie
Ausgabe05/2016
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
Background: Co-transplanted CAR-engineered preTs are an attractive tool for preventing leukemia relapse. The impact on endogenous TCR expression and thereby thymic selection processes remains unclear. Methods: Murine haematopoietic stem cells were transduced with a lentiviral construct containing an inducible CAR against CD19 and then differentiated into preTs in vitro. Engineered preTs were characterised in vitro a…
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Zitierempfehlung
M Maluski, J Herbst, MG Sauer (2016) CAR-engineered precursor T cells (preTs) for leukemia control after hematopoietic stem cell transplantation. Klinische Pädiatrie (05). https://doi.org/10.1055/s-0036-1582500
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