CareLit · DOI-Nachweis · Klinische Pädiatrie
Engineered precursor T cells from human umbilical cord blood using an alpharetroviral vector platform
DOI 10.1055/s-0036-1582502
Bibliografische Angaben
Nachweis in CareLit
Autor:innenJ Hübner, SS Hoseini, JD Suerth, D Hoffmann, M Maluski, J Herbst, B Eiz-Vesper, M Heuser, A Schambach, MG Sauer
ZeitschriftKlinische Pädiatrie
Ausgabe05/2016
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
Background: Alpharetroviral vectors may reduce the risk of insertional mutagenesis. Methods: Cord blood-derived CD34+ cells were transduced and differentiated into preTs in vitro. Two promoter-envelope combinations were comparatively assessed. A chimeric antigen receptor (CAR) against CD123 along with the inducible suicide gene iCaspase 9 were used as genes of interest. Results: The sarcoma virus-derived promoter wi…
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Zitierempfehlung
J Hübner, SS Hoseini, JD Suerth, D Hoffmann, M Maluski, J Herbst, B Eiz-Vesper, M Heuser, A Schambach, MG Sauer (2016) Engineered precursor T cells from human umbilical cord blood using an alpharetroviral vector platform. Klinische Pädiatrie (05). https://doi.org/10.1055/s-0036-1582502
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