CareLit · DOI-Nachweis · Klinische Pädiatrie
Quantification of genomic EWSR1 fusion sequences from plasma of Ewing sarcoma (EwS) patients for therapy monitoring and relapse detection
DOI 10.1055/s-0036-1582508
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Nachweis in CareLit
Autor:innenM Krumbholz, J Hellberg, T Bäuerle, C Gillmann, H Juergens, U Dirksen, M Metzler
ZeitschriftKlinische Pädiatrie
Ausgabe05/2016
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
Background: Cell free circulating tumor DNA (ctDNA) has been shown to represent a biomarker in several common cancers of adulthood, taking advantage of recurrent point-mutations. We evaluated the use of the causative genomic fusion sequence as non-invasive tumor marker in pediatric EwS. Method: Detectability and correlation of EWSR1-FLI1 copies with tumor burden were first explored in EwS xenograft mice. Subsequentl…
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Zitierempfehlung
M Krumbholz, J Hellberg, T Bäuerle, C Gillmann, H Juergens, U Dirksen, M Metzler (2016) Quantification of genomic EWSR1 fusion sequences from plasma of Ewing sarcoma (EwS) patients for therapy monitoring and relapse detection. Klinische Pädiatrie (05). https://doi.org/10.1055/s-0036-1582508
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