CareLit · DOI-Nachweis · Klinische Pädiatrie
Inactive extra-chromosomal MYCN amplicons co-localize to the nuclear lamina in therapy-induced senescent neuroblastoma cells
DOI 10.1055/s-0036-1582511
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Nachweis in CareLit
Autor:innenS Taschner-Mandl, T Gerber, J Blaha, F Kromp, R Foisner, IM Ambros, PF Ambros
ZeitschriftKlinische Pädiatrie
Ausgabe05/2016
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
Introduction: Neuroblastoma (NB) is the most common solid tumour in childhood. MYCN amplification, frequently extrachromosomally, is associated with aggressive tumour behaviour. Metronomic topotecan (TPT) and other drugs can induce cellular senescence, a stable cell cycle arrest, in NB in vitro and in vivo leading to a reduction of MYCN gene copies and abrogation of MYCN expression, however the underlying mechanisms…
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Zitierempfehlung
S Taschner-Mandl, T Gerber, J Blaha, F Kromp, R Foisner, IM Ambros, PF Ambros (2016) Inactive extra-chromosomal MYCN amplicons co-localize to the nuclear lamina in therapy-induced senescent neuroblastoma cells. Klinische Pädiatrie (05). https://doi.org/10.1055/s-0036-1582511
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