CareLit · DOI-Nachweis · Klinische Pädiatrie
CNS germinomas show global demethylation, chromosomal instability and mutational activation of the Kit-, Ras/Raf/Erk- and Akt-pathways
DOI 10.1055/s-0036-1582512
Bibliografische Angaben
Nachweis in CareLit
Autor:innenSL Schulte, A Waha, B Steiger, D Denkhaus, E Dörner, I Leuschner, T Pietsch
ZeitschriftKlinische Pädiatrie
Ausgabe05/2016
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
Introduction: Only limited information is available on their genomic, epigenetic and biological alterations of CNS germinomas. Methods: A genome-wide analysis of chromosomal copy number alterations was performed in 49 CNS germinomas by molecular inversion profiling. CpG methylation was studied by immunohistochemistry of methylated cytosine residues. KIT and RAS family members were sequenced. Ras/Erk and Akt pathway…
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Zitierempfehlung
SL Schulte, A Waha, B Steiger, D Denkhaus, E Dörner, I Leuschner, T Pietsch (2016) CNS germinomas show global demethylation, chromosomal instability and mutational activation of the Kit-, Ras/Raf/Erk- and Akt-pathways. Klinische Pädiatrie (05). https://doi.org/10.1055/s-0036-1582512
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